Levels Chief Medical Officer, Dr. Casey Means, chatted with our advisor, Dr. David Perlmutter on the discovery of how the elevation of uric acid in the body is a causative mechanism in the development of metabolic diseases, and one of the key links between obesity, diabetes, heart disease, neurologic diseases like dementia, ADHD, fatty liver disease, and more.

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They also covered:
- The several mechanisms of how uric acid causes cellular dysfunction and insulin resistance, including oxidative stress, inflammation, and even preventing insulin from getting out of the blood stream effectively.
- The evolutionary reasons why the metabolic dysfunction and weight gain caused by uric acid would have benefitted us historically in terms of low access to food and water, by letting us more easily pack on weight and raise blood pressure. And how we now live in an evolutionary-environmental mismatch where this survival mechanism is now hurting us in the face of caloric abundance.
- The different dietary and environmental factors that generate uric acid, including fructose, purine rich foods and umami foods, dehydration, alcohol, and more.
- The optimal levels for uric acid.
- How uric acid impairs our hunger signals, drives us to eat, and even promotes risk taking behavior. We talked about how to reverse high uric acid levels as a way to unlock optimal health.

00:00 - Intro
03:12 - More than just gout
05:06 - A causative role
07:44 - The number one cause of death
15:24 - Evolutionary environmental mismatch
16:58 - High fructose corn syrup
22:27 - The dangers of uric acid
23:38 - Uric acid and dementia
30:33 - Too much fructose
41:32 - Erectile dysfunction and cardiovascular risk
01:03:17 - No need to eat sugar

Transcript & Show notes: https://www.levelshealth.com/podcasts/116-uric-acid-a-key-cause-of-weight-gain-diabetes-heart-disease-and-dementia-and-simple-steps-to-lower-it-dr-david-perlmutter-dr-casey-means