Paul A. Offit, MD of the Children's Hospital of Philadelphia, returns to JAMA's Q&A series to provide an update on progress in #COVID19 vaccine development. Recorded October 27, 2020.

Check out our video explaining the vaccine frontrunners at https://youtu.be/KMc3vL_MIeo

Topics discussed in this interview:
0:00 Introduction
0:43 Fall spike in cases
2:01 National masking mandate
4:16 Herd immunity and the Great Barrington Declaration
5:50 Vaccine and Related Biologic Products FDA Advisory Committee meeting
6:34 Emergency Use Authorizations (EUAs)
9:43 Is 2 months enough for safety data?
12:10 Next steps for FDA
14:25 Inactivated vaccine from China and Russian vaccine
15:49 Vaccine trials ethical considerations
17:26 COVID-19 vaccines in children
19:08 Vaccine timeline and the election
21:06 ACIP view on EUA applications
22:12 How we knew in 1955 that the polio vaccine was effective
24:11 Hurdles to vaccine distribution

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