Watch as Jenny tries to explain the basic point of Twilight to Lily in an attempt to distract her in the episode "Wrath of the Con". IMHO, this is one of the better explanations of the series.

Jenny: Bella's still in love with him even though he's a vampire. Or maybe it's because he's a vampire. I don't know. But the thing is his family doesn't suck the blood. So it makes her feel safer. But the problem is, is that Edward, the more he falls in love with her the more he wants to *is cut off but probably would've said suck her blood*
*phone ringing*
Lily: Jenny, Jenny, just one minute, Jenny.
Jenny: Okay
Lily: Okay

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Taylor Momsen as Jenny Humphrey
Kelly Rutherford as Lily van der Woodsen/Bass (what is she nowadays?)
Matthew Settle as Rufus Humphrey