Dr. Stephen Shortell provided in his Sam Shapiro lecture real-world examples aimed to bridge the healthcare quality chasm. Inspired by the vision of high performing patient-centered teams and organizations that facilitate them, Dr Shortell employs rigorous quantitative and qualitative methods to understand organizational behavior. The lecture provides a needed road map connecting concepts of behavior and culture change, team dynamics, commitment to value in care, and learning health systems with healthcare redesign, patient engagement, and, ultimately, healthcare performance improvement. The video includes tribute to Sam Shapiro and an exploratory Q&A section.