Use a High Efficiency (HEPA) Air Purifier to remove allergens. The final step for most people in keeping dust mites out of their bedroom is to install a HEPA Air Purifier. Dust mites and their waste products will often become airborne and they are light enough to remain in the air indefinitely.Patti Solano, director of lung health for the Lung Association in Greater Chicago, said air purifiers won't clean the entire home, either. ... She said the best air purifiers use true high-efficiency particulate air (true HEPA) filters, which are proven to trap 99.97 percent of particles of 0.3 microns in size.The wrong type can cause health issues. Filter-based air purifiers produce no by-harmful by-products and are good for your health. They remove harmful and allergy-causing particulates from the air, leaving only fresh air behind. Ozone generators are a poor choice and are potentially harmful.