A patient who has a condition called genetic mosaicism or both male and female DNA is finally told by the Boy's parents with pressure from Thirteen.

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Season 5 Episode 16 "The Softer Side"
The team encounters a teenage boy (Dominic Scott Kay) who collapsed from severe pelvic pain after playing basketball. The boy was born with a condition called genetic mosaicism (46, XX/XY), or both male and female DNA, and the boy's parents inform House and the team that the boy is unaware of his condition. They chose a gender for him when he was born and raised him accordingly. However, when his condition worsens and his life is threatened, the parents wonder whether they made the right decision. Meanwhile, Cuddy and Wilson suspect something is wrong with House when he starts acting way too nice.

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