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Genes | Wikipedia audio article

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This is an audio version of the Wikipedia Article:
https://en.wikipedia.org/wiki/Gene


00:02:00 1 History
00:02:09 1.1 Discovery of discrete inherited units
00:04:26 1.2 Discovery of DNA
00:06:12 1.3 Modern synthesis and its successors
00:06:59 2 Molecular basis
00:07:08 2.1 DNA
00:09:15 2.2 Chromosomes
00:12:04 3 Structure and function
00:12:14 3.1 Structure
00:15:01 3.2 Functional definitions
00:16:48 4 Gene expression
00:17:27 4.1 Genetic code
00:18:28 4.2 Transcription
00:20:19 4.3 Translation
00:21:29 4.4 Regulation
00:22:15 4.5 RNA genes
00:23:20 5 Inheritance
00:23:43 5.1 Mendelian inheritance
00:25:07 5.2 DNA replication and cell division
00:27:04 5.3 Molecular inheritance
00:28:49 6 Molecular evolution
00:28:59 6.1 Mutation
00:31:32 6.2 Sequence homology
00:32:48 6.3 Origins of new genes
00:34:37 7 Genome
00:34:52 7.1 Number of genes
00:36:25 7.2 Essential genes
00:37:47 7.3 Genetic and genomic nomenclature
00:38:28 8 Genetic engineering



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SUMMARY
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In biology, a gene is a sequence of nucleotides in DNA or RNA that codes for a molecule that has a function. During gene expression, the DNA is first copied into RNA. The RNA can be directly functional or be the intermediate template for a protein that performs a function. The transmission of genes to an organism's offspring is the basis of the inheritance of phenotypic trait. These genes make up different DNA sequences called genotypes. Genotypes along with environmental and developmental factors determine what the phenotypes will be. Most biological traits are under the influence of polygenes (many different genes) as well as gene–environment interactions. Some genetic traits are instantly visible, such as eye color or number of limbs, and some are not, such as blood type, risk for specific diseases, or the thousands of basic biochemical processes that constitute life.
Genes can acquire mutations in their sequence, leading to different variants, known as alleles, in the population. These alleles encode slightly different versions of a protein, which cause different phenotypical traits. Usage of the term "having a gene" (e.g., "good genes," "hair colour gene") typically refers to containing a different allele of the same, shared gene. Genes evolve due to natural selection / survival of the fittest and genetic drift of the alleles.
The concept of a gene continues to be refined as new phenomena are discovered. For example, regulatory regions of a gene can be far removed from its coding regions, and coding regions can be split into several exons. Some viruses store their genome in RNA instead of DNA and some gene products are functional non-coding RNAs. Therefore, a broad, modern working definition of a gene is any discrete locus of heritable, genomic sequence which affect an organism's traits by being expressed as a functional product or by regulation of gene expression.The term gene was introduced by Danish botanist, plant physiologist and geneticist Wilhelm Johannsen in 1909. It is inspired by the ancient Greek: γόνος, gonos, that means offspring and procreation.

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