Duke University researcher Diego Bohorquez and colleagues have identified the neural circuitry that connects the gut with the brain. This pathway is spanned by a single synapse, capable of relaying a signal from gut to brain in 100 milliseconds. This newly discovered pathway is probably exploited by pathogens, and will almost certainly lead to new therapies.

Video produced by The Bohórquez Laboratory in the Duke University Departments of Medicine and Neurobiology. More research details available at http://www.gutbrains.com

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The ambition of Bohorquez Lab is to learn how to treat the brain from the gut. Researchers are focused on dissecting the neural circuits that transform signals from food and/or bacteria in the gut into electrical inputs that modulate behaviors like the desire to eat. The laboratory is built on multidisciplinary expertise in viral vector genomics, neurophysiology, behavioral phenotyping, organoid cultures, and neuroimaging. From human miniguts to its own 2Photon –The Wraith– Bohorquez Lab has the pipeline optimized to test ideas from single cells to whole animal behavior.

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