How can we use digital modeling to better understand brain aging and development across individuals and species? The Kasthuri lab at the University of Chicago and Argonne National Laboratory is pioneering new techniques for mapping the fine structure of the brain and nervous system at industrial scale. Bobby Kasthuri will describe these developments, including large volume automated electron microscopy for mapping neuronal connections at the nanoscale, synchrotron source X-ray microscopy for mapping the cellular composition of entire brains—and combining these techniques for multiscale, multimodal brain maps. His lab has applied these tools to the brains of organisms such as octopuses, squids, mice, and primates.

Part of the UChicago Alumni and Friends Harper Lecture Winter 2021 Series. Originally broadcast on March 10, 2021.

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