⏳ David A. Sinclair, PhD, is a professor in the Department of Genetics at Harvard Medical School and co-director of the Paul F. Glenn Center for the Biological Mechanisms of Aging. He is the co-founder of the journal Aging, where he serves as co-chief editor.

Dr. Sinclair's work focuses on understanding the mechanisms that drive human aging and identifying ways to slow or reverse aging's effects. In particular, he has examined the role of sirtuins in disease and aging, with special emphasis on how sirtuin activity is modulated by compounds produced by the body as well as those consumed in the diet, such as resveratrol. His work has implications for human metabolism, mitochondrial and neurological health, and cancer.

Dr. Sinclair obtained his doctoral degree in molecular genetics at the University of New South Wales, Sydney, in 1995. Since then, he has been the recipient of more than 25 prestigious honors and awards and in 2014 was named as one of TIME Magazine’s 100 most influential people in the world. Dr. Sinclair recently authored the book, Lifespan: Why We Age – and Why We Don't Have To.

In this episode, Dr. David Sinclair discusses exciting new findings in the field of aging research, with special emphasis on the roles of sirtuins, resveratrol, and NAD+.

EPISODE LINKS:
Show notes and transcript: https://www.foundmyfitness.com/episodes/david-sinclair?utm_source=youtube&utm_medium=youtube&utm_campaign=sinclair_interview
"Lifespan: Why We Age – and Why We Don't Have To." Book: https://www.simonandschuster.com/books/Lifespan/David-A-Sinclair/9781501191978

PODCAST INFO:
Email: https://www.foundmyfitness.com/newsletter?utm_source=youtube&utm_medium=youtube&utm_campaign=sinclair_interview
Apple Podcasts: https://podcasts.apple.com/us/podcast/049-dr-david-sinclair-on-informational-theory-of/id818198322?i=1000532219203
Spotify: https://open.spotify.com/episode/3QgznDpyAQf4RBaGx54et7
Full interview playlist: https://www.youtube.com/playlist?list=PLJEEAVzHu9KzgkQbe2Thh35VU-HCiId_s
Clips playlist: https://www.youtube.com/playlist?list=PLrGxo-5Uw8gI9-1IStYEvNxVukKxZBlmi

- Learn more in these overview articles:
Sirtuins: https://www.foundmyfitness.com/topics/sirtuin?utm_source=youtube&utm_medium=youtube&utm_campaign=sinclair_interview
Resveratrol: https://www.foundmyfitness.com/topics/resveratrol?utm_source=youtube&utm_medium=youtube&utm_campaign=sinclair_interview
Fasting: https://www.foundmyfitness.com/topics/fasting?utm_source=youtube&utm_medium=youtube&utm_campaign=sinclair_interview
NAD+: https://www.foundmyfitness.com/topics/nad?utm_source=youtube&utm_medium=youtube&utm_campaign=sinclair_interview
Nicotinamide riboside: https://www.foundmyfitness.com/topics/nicotinamide-riboside?utm_source=youtube&utm_medium=youtube&utm_campaign=sinclair_interview
Nicotinamide mononucleotide: https://www.foundmyfitness.com/topics/nicotinamide-mononucleotide?utm_source=youtube&utm_medium=youtube&utm_campaign=sinclair_interview

Chapters:
00:00:00 - Introduction
00:00:36 - Activating longevity genes
00:05:02 - Sirtuin activation
00:07:19 - Fasting, caloric restriction, and exercise
00:10:56 - NAD+
00:16:00 - Resveratrol
00:20:00 - Epigenetics
00:36:22 - Boosting NAD+
00:41:11 - Excess calories accelerates
00:44:26 - Resveratrol slows aging
00:51:00 - NR & NMN in aging
01:00:05 - Sleep improves glucose metabolism

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⏳ #aging #longevity #fasting #epigenetics #NMN #NR 🧬