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Despite Álvarez expressing his desire to avenge his loss against WBA (Super) light heavyweight champion Dmitry Bivol in a rematch, on 24 May 2022 it was announced that Álvarez would instead be returning to the super middleweight division to defend his undisputed titles against Gennady Golovkin in a trilogy bout on 17 September. The bout will see Golovkin, the WBA (Super) and IBF middleweight champion, compete in the super middleweight division for the first time in his career, while it will be Álvarez's sixth bout in the same weight class.

In the first pre-fight press conference on 25 June 2022 in Los Angeles, Álvarez described the rivalry between him and Golovkin as "personal" rather than simply competitive. Álvarez stated of his opponent: “He always pretends to be a nice guy but he’s an asshole. He’s an asshole person... He's talking a lot of things about me. That's why it's personal." Álvarez went on to express his excitement at the prospect of sending his opponent into retirement, and admitted that he received gratification from making Golovkin wait four years for a trilogy bout on his own terms, in his preferred weight class of super middleweight: “It makes me feel good