Detroit Lions at home facing the San Francisco 49ers to kickoff the 2021 NFL Season! Detroit Lions Talk With MicroMike has a full NFL Week 1 preview, featuring analysis, breakdown & final score prediction. See what BetQL has for the odds: https://chatsports.com/lionsql/ to get started now. There are Plenty of Lions news and rumors swirling around this game especially with all the new players and coaches surrounding the Lions. Will the new look Lions be able to pull off a win even though they are a massive underdog in Week 1? And which QB will fare better this week: Jared Goff or Jimmy Garoppolo? The Lions are the underdogs this week at home.

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Lions vs 49ers Week 1 preview! What are the betting odds, point spread and more to watch for this week? The Lions are the favorites, but will they win? Detroit Lions Talk With MicroMike has a complete Lions at home vs 49ers preview this week.

Detroit Lions vs. San Francisco 49ers | NFL Week 1
Spread: Cowboys +7.5
Over/Under: 45.1 Points

Lions vs. 49ers prediction from MicroMike: 49ers win 27-23

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