Bizarre and Mysterious Genetic Mutations in DNA - Strange inbreeding facts in the Royal Family!

You Won't believe these Strange, Mysterious, and sometimes SCARY facts about bizarre genetic mutations that have been caused by inbreeding in the royal family, including hemophilia, cleft palate, club foot and more!

This discovery of mutations in genetics led to strange deaths and diseases that have affected the biology and genes of whole world. Discovery of DNA and RNA brought to you by Zero2Hero!

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Hemophilia, Infertility, and a whole host of life threatening conditions. Genetic mutations in the royal families were passed on through generations of Inbreeding. Stay tuned to number 1 to find out how inbreeding may have helped the United States win the Revolutionary War.
10. Hemophilia
One of the most recognized symptoms of inbreeding, hemophilia, is also one of its most dangerous. Hemophilia is an inherited genetic disease, where the body is unable to clot blood properly due to a lack of the necessary proteins, can often lead to nose bleeds, bruising easily, and even bleeding into the brain. This disease can cause scary situations for patients, such as a simple cut or nose bleed turning into the elevator scene from “The Shining”.
Originally observed and noted by Arabic physician Abulcasis in the 10th Century when he noticed many of his patients dying due to uncontrollable blood loss, the condition became much more well-known and recognized after the devastating effect it had on the family of Queen Victoria I of the United Kingdom. Despite being one of the few female monarchs in English history, and ruling during a time of great change and colonial expansion in her kingdom, hemophilia is one of the most lasting memories of her legacy. In fact researchers believe she was the first carrier of hemophilia B, a new type of the bleeding disorder that she passed on to her descendants. In a trend that will become depressingly common on this list, royal families would often mate with close family members throughout Europe for political and financial reasons. This aided the spread of many genetic mutations, including hemophilia. Originally showing in her son Leopold, who passed away at 30 years old from a minor fall, hemophilia B affected upwards of a dozen relatives in the royal family with the actual gene being passed on to many more. This ultimately led to the death of at least 8 direct descendants.
Thankfully the practice of inbreeding has all but died out in the Western World and today’s descendants of Queen Victoria have decided to try dating outside the family. Good thing, otherwise we wouldn’t know who Pippa is.
9. The Habsburg Jaw (Hapsburg Jaw)
Also known as lantern jaw and Austrian lip, this disorder can cause sufferers serious discomfort due to issues like a misaligned jaw line, swollen lower lip, and enlarged tongue. In severe cases it can also affect the nervous system and lead to mental disabilities, blindness, and seizures.
This condition became much more common among royal families across Europe and the Middle East due to intermarriage among relatives. This type of practice resulted in the most famous case of the Habsburg Jaw and one of its most tragic sufferers, Charles II of Spain. Part of the long-reigning Habsburg House, Charles II became the namesake behind this condition due to his facial abnormalities and slow mental development. By the time he took power in adulthood he had trouble communicating due to his swollen tongue while his severe under bite made chewing extremely difficult.
How did this happen to one of the most powerful houses in European history? Over 100 years of “keeping it in the family” in order to consolidate power. While they are considered one of the more extreme cases, the practice did not stop with the Habsburg House. Other noteworthy rulers dealing with the genetic condition include Ferdinand I of the Holy Roman Empire and Dracula himself, Vlad the Impaler…which certainly explains some things.
8. Club Foot
King Tutankhamun, one of the most widely remembered Pharaohs of the ancient Egyptian world, may have died in a chariot crash or broke his leg during an assassination attempt. For the better part of 100 years, this was the widely believed end of a larger than life figure. However, researchers have recently discovered the evidence behind this cause of death, a severely misaligned foot, was actually due to the young ruler suffering from club foot.
Developed during pregnancy, club foot is an inherited condition of the bones in the feet making them appear twisted and causing the child to have trouble walking. While it is still fairly common to this day, studies indicate that children who are the product of inbreeding have a much higher incidence than the general public.