My guest is Rhonda Patrick, Ph.D. She earned her doctoral degree in biomedical science from St. Jude Children’s Research Hospital at the University of Tennessee Health Science Center and has become one of the leading public health educators on the brain and general health, aging, cancer, and nutrition. We discuss the four major categories of micronutrients that regulate cellular and organ stress and antioxidants, inflammation, hormone regulation, immune system, and longevity. Dr. Patrick provides actionable protocols for obtaining key micronutrients from food and/or supplement-based sources. Additionally, Dr. Patrick outlines protocols for deliberate cold and deliberate heat exposure to benefit metabolism, cardiorespiratory fitness, mental health, and lifespan.

#HubermanLab #Longevity

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Dr. Rhonda Patrick Links
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Article Links
Vitamin D and the omega-3 fatty acids control serotonin synthesis and action, part 2: relevance for ADHD, bipolar disorder, schizophrenia, and impulsive behavior: https://bit.ly/37XbqBF
Role of phosphatidylcholine-DHA in preventing APOE4-associated Alzheimer's disease: https://bit.ly/3wfwDPB
Skin exposure to UVB light induces a skin-brain-gonad axis and sexual behavior: https://bit.ly/3OP5Tha
Human physiological responses to immersion into water of different temperatures: https://bit.ly/3F1ZwCN
Sauna use as a lifestyle practice to extend healthspan: https://bit.ly/3OKdRbv

Other Links
NRF2 Pathway, Moringa & Sulforaphane Supplementation: https://youtu.be/Q0lBVCpq8jc
International Fish Oil Standards: https://bit.ly/3vzqoXI

Timestamps
00:00:00 Dr. Rhonda Patrick – Micronutrients, Cold & Heat Exposure
00:03:12 Momentous Supplements
00:04:27 The Brain-Body Contract
00:05:30 AG1 (Athletic Greens), Thesis, InsideTracker
00:09:42 Stress Response Pathways, Hormesis
00:16:38 Plants, Polyphenols, Sulforaphane
00:21:12 Tools 1: Sulforaphane - Broccoli Sprouts, Broccoli, Mustard Seed
00:23:50 Tool 2: Moringa & Nrf2 Antioxidant Response
00:25:25 Sulforaphane: Antioxidants (Glutathione) & Air Pollution (Benzene Elimination)
00:27:10 Plants & Stress Response Pathways, Intermittent Challenges
00:29:35 Traumatic Brain Injury, Sulforaphane, Nrf2
00:35:08 Tools 3: Omega-3 Fatty Acids (ALA, EPA & DHA), Fish Oil, Oxidation
00:48:40 EPA Omega-3s & Depression
00:52:02 Krill Oil vs. Fish Oil Supplements?
00:54:23 Benefits of Omega-3 Fatty Acids, Omega-3 Index & Life Expectancy
00:59:24 Tool 4: Food Sources of EPA Omega-3s
01:06:07 Omega-3 Supplementation, Omega-3 Index Testing
01:10:22 Benefits of Omega-3s
01:14:40 Tool 5: Food Sources of DHA Omega-3s
01:17:07 Vitamin D & Sun Skin Exposure
01:22:18 Role of Vitamin D, Gene Regulation
01:25:30 Tool 6: Vitamin D Testing & Vitamin D3 Supplementation
01:33:15 Tool 7: Skin Surface Area & Sun Exposure, Vitamin D
01:34:23 Vitamin D & Longevity
01:36:46 Sun Exposure & Sunscreen
01:40:30 Role of Magnesium, Magnesium Sources, Dark Leafy Green Vegetables
01:44:50 Tool 8: Magnesium Supplements: Citrate, Threonate, Malate, Bisglycinate
01:50:57 Tool 9: Deliberate Cold Exposure Protocol & Mood/Anxiety
01:59:22 Tool 10: Cold Exposure, Mitochondria UCP1 & Heat Generation
02:02:30 Tool 11: Cold & Fat ‘Browning’, PGC-1alpha, Metabolism
02:05:08 Cold Exposure & High-Intensity Interval Training (HIIT), PGC-1alpha, Muscle
02:08:04 Tools 12: Exercise, HIIT, Tabata & Sauna
02:13:30 Tool 13: Sauna, Endorphins/Dynorphins, Mood
02:17:45 Tool 14: Mild Stress, Adrenaline & Memory
02:19:53 Sauna, Vasodilation & Alzheimer’s and Dementia Risk
02:25:30 Sauna Benefits, Cardiorespiratory Fitness, Heat Shock Proteins (HSPs)
02:31:29 Insulin signaling, FOXO3 & Longevity
02:33:22 Tools 16: Sauna Protocols, Hot Baths & Fertility
02:37:41 Tool 17: Exercise & Longevity, Osteocalcin
02:41:37 Tools 18: Red Light Sauna? Infrared Sauna? Sauna & Sweating of Heavy Metals
02:47:20 FoundMyFitness Podcast, Zero-Cost Support, YouTube Feedback, Spotify & Apple Reviews, Sponsors, Patreon, Momentous Supplements, Huberman Lab on Instagram & Twitter

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Title Card Photo Credit: Mike Blabac - https://www.blabacphoto.com