My guest is Casey Halpern, M.D., Chief of Stereotactic and Functional Neurosurgery and Professor of Neurosurgery at the Perelman School of Medicine at the University of Pennsylvania. Dr. Halpern’s research and clinical practice focus on using deep brain stimulation to treat compulsive and movement disorders (e.g., binge eating disorders, bulimia, obsessive-compulsive disorder (OCD) and Parkinson’s disease essential tremor, dystonia). We discuss using deep brain stimulation to help patients who suffer from movement and compulsive disorders and applying this treatment to patients afflicted with binge eating. We also explore applications of this technology to other conditions such as OCD, anorexia and tremor, and the future therapeutic directions of the use of non-invasive brain stimulation approaches, including transcranial magnetic stimulation and ultrasound, for the treatment of other psychiatric illnesses and conditions. This episode will interest those curious about the biology of eating, anorexia, bulimia, compulsive thoughts and behaviors, and movement.

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Dr. Casey Halpern
Penn Medicine Profile: https://www.pennmedicine.org/providers/profile/casey-halpern
Twitter: https://twitter.com/halpernc
LinkedIn: https://www.linkedin.com/in/casey-halpern-a1569749
Responsive Neurostimulation For Loss Of Control Eating (DBSLOC) Study: https://www.clinicaltrials.gov/ct2/show/NCT03868670

Articles
Pilot study of responsive nucleus accumbens deep brain stimulation for loss-of-control eating: https://go.nature.com/3Sc1ZA1

Timestamps
00:00:00 Dr. Casey Halpern & Disordered Eating & Brain Stimulation
00:03:18 ROKA, Eight Sleep, InsideTracker
00:07:19 Momentous Supplements
00:08:28 Neurosurgeon’s View of the Brain, Neurosurgery Specialization
00:13:05 Deep Brain Stimulation & Other Unexpected Positive Effects
00:17:20 Obsessive Compulsive Disorder (OCD), Prescriptions & Cognitive Therapies
00:25:40 Brain Areas in OCD, Risk, Rewards & Addiction
00:31:11 AG1 (Athletic Greens)
00:32:27 Facial and Vocal Ticks, Stimulants, Stress & Superstition
00:39:28 Nucleus Accumbens, Reward Circuits, Eating Disorders & Obesity
00:47:18 Stimulation of Nucleus Accumbens, Continuous vs. Episodic Stimulation
00:49:49 Binge Eating Disorder & Loss of Control Eating
00:53:02 Developing Binge Eating Disorder: Predisposition, Environment, Stress
01:02:07 Electrodes in Nucleus Accumbens, Identifying “Craving Cells”
01:11:41 Effects of Stimulation, Interrupting Craving, Intermediate Stimulation
01:16:46 Anorexia, Obesity & Compulsions, Potential Treatments for Anorexia
01:23:14 Non-Invasive Brain Stimulation, Transcranial Magnetic Stimulation
01:32:27 MRI-Guided Focused Ultrasound: Tremor, Essential Tremor & Parkinson’s
01:36:40 Future of Non-Invasive Brain Stimulation, Epilepsy & Depression
01:41:51 Pre-Behavioral States in Compulsion & Awareness, Mood Provocation
01:48:02 Machine Learning/Artificial Intelligence & Compulsion Predictions
01:53:05 Neurosurgeon Hands, Resistance Training & Deadlifts
01:59:00 “Neurosurgeon Calm,” Quality Time & Prioritization, Neurosurgeon Training
02:09:53 Daily Habits: Sleep, Exercise, Mediation
02:11:59 Zero-Cost Support, YouTube Feedback, Spotify & Apple Reviews, Sponsors, Momentous Supplements, Neural Network Newsletter, Instagram, Twitter, Facebook, LinkedIn

The Huberman Lab Podcast is for general informational purposes only and does not constitute the practice of medicine, nursing or other professional health care services, including the giving of medical advice, and no doctor/patient relationship is formed. The use of information on this podcast or materials linked from this podcast is at the user’s own risk. The content of this podcast is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Users should not disregard or delay in obtaining medical advice for any medical condition they may have and should seek the assistance of their health care professionals for any such conditions.

Title Card Photo Credit: Mike Blabac - https://www.blabacphoto.com