Somewhere in a parallel universe, Isaiah Washington portrays Derek Shepherd aka McDreamy, and Sandra Oh portrays Miranda Bailey... Can you imagine that everyone's favorite's role as Derek Shepherd could be portrayed by another actor? Find out why Ellen Pompeo wasn't fond of that idea!

01:18 Derek's (Patrick Dempsey) marriage to his first wife, Addison (Kate Walsh), gave us so many reasons to worry in the early seasons of the Grey's Anatomy! Find out what went wrong on the set!

2:44 Chyler Leigh's (Lexie Grey) departure from the show became one of the most tragic plot twists of the show. Find out shocking details about her last days on the set of Grey's Anatomy.

04:31 Did you know how Shonda Rhimes dealt with Ellen Pompeo's, Sarah Drew's, Chandra Wilson's and other actresses pregnancies?

05:35 Justin Chambers revealed that Alex Karev was brought on after the pilot episode was filmed. Can you imagine Grey's Anatomy without him?

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