Chakri (J.D Chakravarthy) and Madhu (Urmila Matondkar) are neighbours who love each other. Their parents who don't get along with each other do not approve of their love. The film involves the comic travails of the couple eloping. While on the run from their parents, they become the prime suspects in the Assassinate of a politician. Now, they must run from the cops, the mafia and their parents while trying to prove their innocence. Anaganaga Oka Roju is written and directed by Ram Gopal Varma.