Forever chemicals are used in everything from rain jackets to jet fuel. But the chemistry behind what makes them useful also makes them stick around in the environment and us...forever?

#pfas #foreverchemicals #pfoa #genx #pfos

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Credits:
Executive Producers:
George Zaidan
Hilary Hudson

Producers:
Andrew Sobey
Elaine Seward

Writer/Host:
Sam Jones, PhD

Scientific consultants:
David Andrews, PhD
Jamie DeWitt, PhD
Leila Duman, PhD
Cheryl Hogue
Brianne Raccor, PhD

Sources:
First study on PFAS binding to human serum
https://www.jbc.org/article/S0021-9258(18)65805-3/pdf

PFAS Half-Life
https://www.nrdc.org/sites/default/files/media-uploads/nrdc_pfas_report.pdf

Albumin is the major carrier protein for PFOS, PFOA, PFHxS, PFNA and PFDA in human plasma
https://www.sciencedirect.com/science/article/pii/S0160412019331964

PFAS in the environment
https://www.tn.gov/content/dam/tn/environment/solid-waste/documents/esos/sw_esos-13_2018-05-16-1540-jones.pdf

An overview of the uses of per- and polyfluoroalkyl substances (PFAS)
https://pubs.rsc.org/en/content/articlelanding/2020/em/d0em00291g#!divAbstract

Understanding organofluorine chemistry. An introduction to the C–F bond
https://pubs.rsc.org/en/content/articlelanding/2008/cs/b711844a/unauth#!divAbstract

EPA Takes Action to Address PFAS in Drinking Water
https://www.epa.gov/newsreleases/epa-takes-action-address-pfas-drinking-water

The hunt is on for GenX chemicals in people
https://cen.acs.org/environment/persistent-pollutants/hunt-GenX-chemicals-people/97/i14

Scientific Basis for Managing PFAS as a Chemical Class
https://pubs.acs.org/doi/10.1021/acs.estlett.0c00255


A review of the pathways of human exposure to poly- and perfluoroalkyl substances (PFASs) and present understanding of health effects
https://pubmed.ncbi.nlm.nih.gov/30470793/

‘Forever chemicals’ no more? These technologies aim to destroy PFAS in water
https://cen.acs.org/environment/persistent-pollutants/Forever-chemicals-technologies-aim-destroy/97/i12

Deposition of PFAS 'forever chemicals' on Mt. Everest
https://pubmed.ncbi.nlm.nih.gov/33353778/

A review of the emerging treatment technologies for PFAS contaminated soils
https://pubmed.ncbi.nlm.nih.gov/32063301/

Human exposure to per- and polyfluoroalkyl substances (PFAS) through drinking water: A review of the recent scientific literature
https://pubmed.ncbi.nlm.nih.gov/31421451/

PFAS guide
https://cen.acs.org/sections/pfas.html

PFAS Research
https://www.niehs.nih.gov/research/programs/pfas/index.cfm

Endocrine Disruption of Androgenic Activity by Perfluoroalkyl Substances: Clinical and Experimental Evidence
https://academic.oup.com/jcem/article/104/4/1259/5158211

EPA Action Plan (2019)
https://www.epa.gov/sites/production/files/2019-02/documents/pfas_action_plan_021319_508compliant_1.pdf

PFAS FDA
https://www.fda.gov/food/chemicals/and-polyfluoroalkyl-substances-pfas

Contamination map in US
https://www.ewg.org/interactive-maps/pfas_contamination/map/

Accumulation of perfluoroalkyl substances in human tissues
https://www.sciencedirect.com/science/article/pii/S0160412013001220

High Levels Of ‘Forever Chemicals’ Detected In Northern Virginia Drinking Water
https://dcist.com/story/21/03/10/high-levels-toxic-pfas-forever-chemicals-northern-virginia-drinking-water/

PFAS fact sheet
https://www.ngwa.org/docs/default-source/default-document-library/pfas/pfastop-10.pdf?sfvrsn=8c8ef98b_2#:~:text=Studies%20have%20estimated%2095%20percent,%2C%20inhalation%2C%20and%20occupational%20contact.

Accumulation of perfluoroalkyl substances in human tissues
https://www.sciencedirect.com/science/article/pii/S0160412013001220?via%3Dihub

Binding of PFOS to serum albumin and DNA: insight into the molecular toxicity of perfluorochemicals
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2656506/

How to say goodbye to PFAS
https://cen.acs.org/environment/persistent-pollutants/say-goodbye-PFAS/97/i46

Viscous Microemulsions of Aqueous Film-Forming Foam (AFFF) and Jet Fuel A Inhibit Infiltration and Subsurface Transport
https://pubs.acs.org/doi/10.1021/acs.estlett.0c00868


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